LCMS-2020
High speed. High sensitivity. High resolution. High performance.
Simply put, the new Shimadzu LCMS-2020 is the world’s most sensitive, fastest scanning and fastest polarity switching quadrupole mass spectrometer available.
Building an LC/MS system that employs an MS as an LC detector can effectively reduce the limitations of LC analysis. In addition to this, reducing those limitations to the greatest extent possible requires an MS that can handle ultra high speed analysis. The new "LCMS-2020" single quadrupole ultra-fast LC/MS, boldly addresses these requirements. It is capable of providing more data points and faster scans than any previous quadrupole LCMS instrument, allowing it to handle the fastest small-particle and high efficiency columns.
Delivering the ultimate in measurement speed and sensitivity, the compact LCMS-2020 mass spectrometer offers faster measurements and higher detection sensitivity for quicker and more accurate detection of trace impurities, environmental pollutants, and other contaminants. When combined with a Prominence ultra-fast LC (UFLC/UFLCXR), you’ll achieve the ultimate in separation performance and productivity.
From HPLC to UFLC
UFLC achieves excellent speed and resolution, while offering the high precision not available with conventional HPLC and expandability options.
UFswitching Technology
High-speed polarity switching between positive/negative ion modes
Not only high-speed analysis, but increased overall speed through rapid sample injection and fully automatic analysis functions. Measuring unknown substances requires measuring in both positive and negative ion modes. Since the positive ion/negative ion polarity switching speed of most LCMS systems is slow, ultra-fast analysis requires injecting samples twice for separate measurements. UFswitching technology (patent pending) enables switching between positive and negative ion modes in 15 milliseconds so even the fastest LC peaks can be analyzed in both modes, thus increasing productivity.
Unquestionable Fidelity
UFLC offers exceptional injection reproducibility as well as ultrahigh-speed operation. In terms of minimizing sample carryover,
essential in LC/MS analysis, the LCMS-2020 stays ahead of the competition.
UFsensitivity
Superior sensitivity, especially for ultra high-speed analysis
Innovative ion optics with the newly developed Qarray® ion optical system, provide superior sensitivity, repeatability, and linearity, achieving 50% to 300% greater sensitivity than any other single quadrupole analyzer for substances most commonly measured.
UFscanning Technology
Fast scanning speeds
By adopting new technology (patent pending), a scanning speed of 15,000 u/sec is achieved without sacrificing sensitivity or resolution, even during high-speed scans.
Ultra Flexible
Covers an extensive range: from ultra-fast analysis to conventional HPLC and semi-preparative analysis.
Toughness against dirty samples
In order to check the toughness of the LCMS-2020 against dirty samples, plasma samples simply precipitated with only acetonitrile were injected 2,500 times over 10 days (1µL volume per injection). Excellent reproducibility of peak area was demonstrated and its RSD was 2.26%.
Creating Fragment Ions by In-source CID
In-source CID (collision-induced dissociation) is effective for confirming the molecular weight of synthetic compounds and for the quantification of impurities. Using in-source CID allows the generation of fragment ions.
This example shows the composition of impurities in erythromycin estimated from fragment ions generated by
in-source CID. The multi-sequence mode permits several other methods within a single analysis, such as CID, positive/negative ion switching modes, and SCAN/SIM modes. Precisely setting the parameters reduces the risk of erroneous evaluations and enhances the reliability of analysis results.
Easy Operation/Maintenance
The ESI method typically used for LCMS can be replaced with APCI, which is suitable for neutral compounds, or with a dual ionization source (DUIS) for simultaneous operation of both ionization modes, quickly and without tools. Selection of the DUIS ionization mode (ESI or APCI) can be performed via the computer. In addition, the desolvation line (DL) that introduces the sample from the ion source into the vacuum can be installed and uninstalled without breaking the vacuum, which dramatically enhances ease-of-maintenance.
Software
LCMSsolution includes an improved data browser function to help qualitative processing of multiple sets of data.
This data browser allows comparing multiple sets of data or confirming impurities by linking to LC or MS data, which is especially helpful for users in fields where compounds are synthesized, such as pharmaceuticals and chemical products.
In addition, manual peak integration can be conducted on both LC and MS chromatograms simultaneously,
and a variety of formats are available for easier and more convenient reporting.
Click here for more information on the LCMSsolution Software
